MORPHOLOGICAL FEATURES OF THE LIVER IN POLYPRAGMASIA
Keywords:anti-inflammatory, drugs, hepatotoxicity, pharmacotherapy, liver
Studies of the morphofunctional state of the liver attract the attention of specialists in morphology and clinical biochemistry due to its essential role in metabolism, synthesis of proteins and lipoproteins in blood plasma, conjugation of bilirubin and formation of bile, detoxification, and other essential functions. In recent years, there has been a clear trend towards increased the number of drug lesions due to the growing expansion of the pharmaceutical market. Thus, in Japan, over 30 years, an 11- fold increase in drug hepatotoxicity was recorded. The cause of the development of acute drug liver damage (DILI) can be more than 1200 drugs, 200 of which are potentially hepatotoxic. According to pharmacoepidemiological studies, DILI most often develops against the background of non-steroidal anti-inflammatory drugs (NSAIDs), antimicrobial drugs, and drugs that affect the central nervous system (CNS), which is due not only to their potential hepatotoxicity but also to widespread use. 40% of all cases of acute hepatitis in patients aged 40 and over and 13–25% of cases of fulminant liver failure (FPI) are due to drug-induced hepatotoxicity. Medicinal hepatitis complicates the ongoing pharmacotherapy in 1–28% of cases, and 12–25% of cases contribute to the development of liver cirrhosis and liver failure.
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