PLACENTAL INSUFFICIENCY IN PREGNANT WOMEN WITH DIABETES MILLETUS
Keywords:Placenta, vascularisation, invasion, insulin, lipids
Placental insufficiency (PN) is a syndrome consisting of a complex of disorders of the trophic, endocrine and metabolic functions of the placenta, leading to its inability to maintain an adequate and sufficient exchange between the body of the mother and the fetus. Fetoplacental insufficiency can develop in a number of somatic diseases of a woman, chronic infections of endocrinopathies (diabetes mellitus (DM), hypo- and hyperfunction of the thyroid gland, pathology of the hypothalamus and adrenal glands) and a number of other pathological conditions. Among a number of factors that form the normal homeostasis of the fetus, of course, a significant role is played not only by the state of health of the mother, not only the genetic program of the development of the fetus, but also by the morpho-functional usefulness of the placenta. In the development of this syndrome, two main pathways of formation can be distinguished. They can exist independently or be combined with each other: 1. Trophic insufficiency, in which the absorption and assimilation of nutritious foods is disturbed, as well as the synthesis of the fetus's own metabolic products. 2. Respiratory failure, consisting in impaired transport of oxygen and carbon dioxide.
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